4.7 Article

Dextran-Based Self-Healing Hydrogels Formed by Reversible Diels-Alder Reaction under Physiological Conditions

期刊

MACROMOLECULAR RAPID COMMUNICATIONS
卷 34, 期 18, 页码 1464-1470

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201300494

关键词

dextran; hydrogels; self-healing

资金

  1. National Natural Science Foundation of China [51073127, 51173144, 21105079]
  2. Research Fund for the Doctoral Program of Higher Education of China [20100201110040]
  3. Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
  4. Fundamental Research Funds for the Central Universities [2009-0109-08140018, 2011-0109-08143038]
  5. Ministry of Science and Technology of China
  6. Shaanxi Province
  7. New Research Support Project of Xi'an Jiaotong University, P.R. China
  8. Major International Joint Research Program of China [11120101002]
  9. National 111 Project of China [B06024]
  10. International Science & Technology Cooperation Program of China [2013DFG02930]

向作者/读者索取更多资源

A dextran-based self-healing hydrogel is prepared by reversible Diels-Alder reaction under physiological conditions. Cytocompatible fulvene-modified dextran as main polymer chains and dichloromaleic-acid-modified poly(ethylene glycol) as cross-linkers are used. Both macro- and microscopic observation as well as the rheological recovery test confirm the self-healing property of the dextran-l-poly(ethylene glycol) hydrogels (l means linked-by). In addition, scanning electrochemical microscopy is used to qualitatively and quantitatively in situ track the self-healing process of the hydrogel for the first time. It is found that the longitudinal depth of scratch on hydrogel surface almost completely healed at 37 degrees C after 7 h. This work represents a facile approach for fabrication of polysaccharide self-healing hydrogel, which can be potentially used in several biomedical fields.

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