期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 34, 期 3, 页码 269-273出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201200605
关键词
cell encapsulation; eosin-Y; hydrogels; photopolymerization; thiol-ene chemistry
资金
- Department of Biomedical Engineering at IUPUI
- IUPUI Office of the Vice Chancellor for Research (OVCR)
- Indiana Diabetes Research Center at IU School of Medicine
- NIH/NIBIB [R21EB013717]
The utility of visible-light-mediated polymerization in tissue engineering has been limited due to the necessary use of potentially cytotoxic coinitiator and comonomer. Here, we report a visible-light-mediated thiol-ene hydrogelation scheme using eosin-Y as the only photoinitiator. Under visible light exposure, rapid and highly tunable step-growth gelation is achieved using PEG-norbornene and a model cross-linker dithiothreitol. In addition to investigating the gelation kinetics and properties of thiol-ene hydrogels formed by this new gelation scheme, we also report high cytocompatibility of these hydrogels using human mesenchymal stem cells (hMSCs) and pancreatic MIN6 beta-cells.
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