期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 35, 期 4, 页码 442-446出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201300585
关键词
anticancer; DMAEMA; hydrogels; sustained release; triazole
资金
- Priority Research Center Program through the National Research Foundation of Korea [2009-0093818]
- Basic Science Research Program through the National Research Foundation of Korea [2012R1A1A2039730]
- Ministry of Education, Science, and Technology of Korea
- Korea Healthcare Technology RAMP
- D Project, Ministry for Health, Welfare and Family Affairs [A110096]
- Korea Health Promotion Institute [A110096] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012R1A1A2039730] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The purpose of this study is to develop novel triazole-containing hydrogels (TGs) as drug carrier and to investigate the sustained drug release accomplished by their time-dependent swelling behavior. The synthetic pathway of TGs includes: (1) DCC-coupling on hydroxyethyl methacrylate (HEMA) to prepare HEMA-alkyne (HA), (2) click-coupling to prepare a triazole-ring-containing monomer (TM), and (3) the synthesis of a series of TGs. The aggregation between triazole rings is found to be responsible for drug release controllability. Rhodamine 6G is studied as a model anticancer drug for release experiments. The effects of pH and temperature on the properties of sustained drug release are also studied.
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