期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 34, 期 8, 页码 635-639出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201200823
关键词
antibacterial; carboxybetaine ester; dsDNA polyplex; photochemistry; water-soluble polymers
资金
- VEGA Grant Agency [2/0152/10]
- Slovak Research and Development Agency [APVV-0282-11, APVV-0486-10]
- EFSD New Horizons grant
A novel cationic polymer poly(N,N-dimethyl-N-[3-(methacroylamino) propyl]-N-[2-[(2-nitrophenyl)methoxy]-2-oxo-ethyl]ammonium chloride) is synthesized by free-radical polymerization of N-[3-(dimethylamino)propyl] methacrylamide and subsequent quaternization with o-nitrobenzyl 2-chloroacetate. The photolabile o-nitrobenzyl carboxymethyl pendant moiety is transformed to the zwitterionic carboxybetaine form upon the irradiation at 365 nm. This feature is used to condense and, upon the light irradiation, to release double-strand DNA tested by gel electrophoresis and surface plasmon resonance experiments as well as to switch the antibacterial activity to non-toxic character demonstrated for Escherichia coli bacterial cells in solution and at the surface using the self-assembled monolayers.
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