期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 34, 期 17, 页码 1387-1394出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201300477
关键词
biocompatibility; mesoporous silica nanoparticles; RAFT polymerization; redox-responsive release
资金
- National Science Foundation of China [21074121, 21090354]
- China Postdoctoral Science Foundation [2013M531512]
- Fundamental Research Funds for the Central Universities [WK2060200011]
A versatile one-pot strategy for the preparation of reversibly cross-linked polymer-coated mesoporous silica nanoparticles (MSNs) via surface reversible addition-fragmentation chain transfer (RAFT) polymerization is presented for the first time in this paper. The less reactive monomer oligo(ethylene glycol) acrylate (OEGA) and the more reactive cross-linker N,N-cystaminebismethacrylamide (CBMA) are chosen to be copolymerized on the external surfaces of RAFT agent-functionalized MSNs to form the cross-linked polymer shells. Owing to the reversible cleavage and restoration of disulfide bonds via reduction/oxidation reactions, the polymer shells can control the on/off switching of the nanopores and regulate the drug loading and release. The redox-responsive release of doxorubicin (DOX) from this drug carrier is realized. The protein adsorption, in vitro cytotoxicity assays, and endocytosis studies demonstrate that this biocompatible vehicle is a potential candidate for delivering drugs. It is expected that this versatile grafting strategy may help fabricate satisfying MSN-based drug delivery systems for clinical application.
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