期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 31, 期 12, 页码 1078-1082出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200900866
关键词
click chemistry; glycopolymer; lectin recognition; microporous poly(propylene) membrane; photografting
资金
- National Natural Science Foundation of China for Distinguished Young Scholars [50625309]
- National Natural Science Foundation of China [50933006]
- National Basic Research Program of China [2009CB623401]
To biologically mimic the carbohydrate-protein interactions in artificial systems, one of the challenges is to construct a glycosylated surface with a high glycosyl density to yield a notable 'glycoside cluster effect'. A novel strategy is presented for high density glycosylation of the surface of a microporous poly(propylene) membrane (MPPM) by click chemistry. It is promising that the surface glycosyl density can be well controlled over a wide range and the maximum value is over 10 mu mol.cm(-2). The recognition capability of these glycosylated MPPMs to lectins indicates the occurrence of the 'glycoside cluster effect' when the glycosyl density on the membrane surface exceeds 0.20 mu mol.cm(-2).
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