期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 30, 期 13, 页码 1109-1115出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200900205
关键词
films; nanoparticles; polyelectrolytes; self-assembly; sensors
资金
- Korean Government (MEST) [R01-2007-000-11930-0, R11-2007-050-03003-0]
- National Research Foundation of Korea [과C6B1913, R11-2007-050-03003-0, R01-2007-000-11930-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We have created a new functional biosensor coating composed of polyelectrolyte multilayers containing gold nanoparticles. This gold-hybridized polyelectrolyte multilayer film possesses a stable nanoporous structure under physiological conditions. Antibody molecules were successfully conjugated onto the gold nanoparticles within the film. This functional coating successfully extinguished false signals from non-specific binding of proteins and cells and also provided highly enhanced detection sensitivity. Furthermore, the drastic differences in protein and cellular adhesion properties between a chip coated with the nanoporous PEM film and a bare chip demonstrate that morphological control of biological interactions on chip surfaces is possible.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据