期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 29, 期 22, 页码 1775-1792出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200800381
关键词
biological applications of polymers; biomaterials; electrospinning; fibers
资金
- David and Lucile Packard Foundation
- AFOSR-MURI
- School of Materials Science and Engineering
- Tianjin University
Electrospinning has been exploited for almost one century to process polymers and related materials into nanofibers with controllable compositions, diameters, porosities, and porous structures for a variety of applications. Owing to its high porosity and large surface area, a non-woven mat of electrospun nanofibers can serve as an ideal scaffold to mimic the extracellular matrix for cell attachment and nutrient transportation. The nanofiber itself can also be functionalized through encapsulation or attachment of bioactive species such as extracellular matrix proteins, enzymes, and growth factors. In addition, the nanofibers can be further assembled into a variety of arrays or architectures by manipulating their alignment, stacking, or folding. All these attributes make electrospinning a powerful tool for generating nanostructured materials for a range of biomedical applications that include controlled release, drug delivery, and tissue engineering.
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