期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 29, 期 20, 页码 1655-1660出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200800459
关键词
anisotropic; biodegradable; biofibers; biomaterials; click-chemistry
资金
- National Institutes of Health [5 R21 EB005732-02]
- Department of Defense [W81XWH-06-1-0271]
Precise nano- and microscale control of the architecture of biodegradable biomaterials is desirable for several biotechnological applications such as drug delivery, diagnostics, and medical imaging. Herein, we combine electrohydrodynamic co-jetting and highly specific surface modification (via Huisgen 1,3-dipolar cycloaddition) to prepare particles and fibers with spatioselective surface modification. We first prepared biphasic particles and fibers from commercial poly(lactide-co-glycolide) copolymers via electrohydrodynamic co-jetting of two organic solutions loaded with fluorescent macromolecules and acetylene-modified PLGA derivatives. (i) Spatially controlled reaction of poly [lactide-co-(propargyl glycolide)] with O-(2-aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol and (ii) subsequent conversion of the newly introduced amino groups with fluorescence probes resulted in particles and fibers with surface modification of one hemisphere only.
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