期刊
MACROMOLECULAR MATERIALS AND ENGINEERING
卷 297, 期 12, 页码 1193-1202出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.201200241
关键词
flexible electronics; neural interfaces; shape memory polymers; stimuli-sensitive polymers; thermosets
资金
- National Institutes of Neurological Disorders and Stroke [5R01DC008982]
- National Science Foundation [1114211, 2011113646]
- State of Texas
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1114211] Funding Source: National Science Foundation
Planar electronics processing methods have enabled neural interfaces to become more precise and deliver more information. However, this processing paradigm is inherently 2D and rigid. The resulting mechanical and geometrical mismatch at the biotic abiotic interface can elicit an immune response that prevents effective stimulation. In this work, a thiol-ene/acrylate shape memory polymer is utilized to create 3D softening substrates for stimulation electrodes. This substrate system is shown to soften in vivo from more than 600 to 6 MPa. A nerve cuff electrode that coils around the vagus nerve in a rat and that drives neural activity is demonstrated.
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