Click Chemistry as a Facile Approach to the Synthesis of Polyphosphazene Glycopolymers

A versatile approach based on click chemistry to synthesize polyphosphazene glycopolymers is presented. The glucose-substituted polyphosphazene was synthesized by nucleophilic substitution of poly(dichlorophosphazene) with propargylamine and the subsequent azide/alkyne click reaction of poly[di(propargyl-amine)phosphazene] (PDPAP) with azidosugar. The relative proportion of the glucose substituent can be easily controlled over a broad range by varying the amount of azidoglucose used in the azide/alkyne click reaction.