期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 210, 期 6, 页码 467-477出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.200800496
关键词
folic acid; microgels; NMR; NPA; pH-responsive
资金
- MCYT
Colloidal nanosized folate-conjugated hydrogels for targeted chemotherapy were prepared via a versatile and efficient postsynthetic modification pathway starting from P(NPA-co-NIPAM). The modifications included the introduction of 4-methylpyridine as pH-sensitive pendant groups and the conjugation of folic acid to the microgel network. The microgels showed a specific swelling at pH < 6 (endosomes) as judged by DLS studies varying the external pH. The relative composition of the microgels shows a clear influence on the pH volume transition shifting. The potential of the microgels for anticancer drug release at pH = 5.0 was confirmed. Therefore, they are a promising targeting carrier for improved anticancer chemotherapy.
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