期刊
MACROMOLECULAR BIOSCIENCE
卷 19, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201800221
关键词
beta-sheet and helical peptides; biopolymers; collagen mimetic peptides; conjugation; hydrogels; peptide-polymer hybrids; self-assembly
资金
- European Union (CIG Grant SuprHApolymers,) [PCIG14-GA-2013-631871]
- Royal Society [RSG\R1\180005]
Peptides and polymers are the elite building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses (adhesion, migration, differentiation). However, the use of polymers and peptides as structural components for fabricating supramolecular hydrogels is less well established. Here, the literature on the design of peptide/polymer systems for self-assembly into hybrid hydrogels, as either peptide-polymer conjugates or combining both components individually, is reviewed. The properties (stiffness, mesh structure, responsiveness, and biocompatibility) of the hydrogels are then discussed from the viewpoint of their potential biomedical applications.
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