期刊
MACROMOLECULAR BIOSCIENCE
卷 14, 期 5, 页码 731-739出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300406
关键词
degradation; hydrogels; matrix metalloproteinases; PEGDA; porosity
资金
- National Science Foundation [EEC-1157041]
- Pritzker Institute of Biomedical Science and Engineering at the Illinois Institute of Technology
Proteolytically degradable poly(ethylene) glycol (PEG) hydrogels have been investigated as tissue engineering scaffolds; however, cell invasion and tissue regeneration are limited by the rate of cell-mediated degradation due to the small mesh size of the resultant crosslinked network. Gelatin leaching is combined with photopolymerization to form porous matrix-metalloproteinase (MMP)-sensitive PEG scaffolds under cytocompatible conditions in the presence of cells. Gelatin leaching allows control over pore size and porosity through selectivity of gelatin bead particle size and porogen loading, respectively. Increases in porogen loading lead to increased porosity, decreased compressive modulus and degradation time, and enhanced proliferation of encapsulated vascular smooth muscle cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据