期刊
MACROMOLECULAR BIOSCIENCE
卷 14, 期 11, 页码 1514-1520出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400306
关键词
3D printing; additive manufacturing; electrospinning; endothelial cells; microcirculation
资金
- NHLBI [HL089658]
- NSF [DMR-1206589]
- University of Pittsburgh
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1206589] Funding Source: National Science Foundation
Sufficient vascularization is critical to sustaining viable tissue-engineered (TE) constructs after implantation. Despite significant progress, current approaches lack suturability, porosity, and biodegradability, which hinders rapid perfusion and remodeling in vivo. Consequently, TE vascular networks capable of direct anastomosis to host vasculature and immediate perfusion upon implantation still remain elusive. Here, a hybrid fabrication method is presented for micropatterning fibrous scaffolds that are suturable, porous, and biodegradable. Fused deposition modeling offers an inexpensive and automated approach to creating sacrificial templates with vascular-like branching. By electrospinning around these poly(vinyl alcohol) templates and dissolving them in water, microvascular patterns were transferred to fibrous scaffolds. Results indicated that these scaffolds have sufficient suture retention strength to permit direct anastomosis in future studies. Vascularization of these scaffolds is demonstrated by in vitro endothelialization and perfusion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据