期刊
MACROMOLECULAR BIOSCIENCE
卷 14, 期 8, 页码 1190-1198出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400023
关键词
biphasic calcium phosphate; bone tissue engineering; gamma-ray irradiation; RGD peptide; surface modification
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2012M2A2A6013196]
- National Research Foundation of Korea [2012M2A2A6013196] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Over the last decade, bone tissue engineering scaffolds have been advanced owing to the bioceramic incorporation and biomimetic modification. In this report, a dual-functional fibrous scaffold with a bioceramic and biomolecule is developed, and a combined effect of a dual-modification is investigated. Biphasic calcium phosphate (BCP) is incorporated in electrospun poly (L-lactide) scaffolds, and Arg-Gly-Asp (RGD) peptide is then conjugated through the graft polymerization of acrylic acid by g-ray irradiation. The scaffolds exhibit the intrinsic properties of BCP as well as RGD peptide, and only RGD peptide improves an adhesion and proliferation of the human mesenchymal stem cell. However, alkaline phosphatase activity and calcium formation are synergistically improved by the BCP and RGD peptide indicating that a favorable microenvironment is constructed for bone formation. Therefore, this combination strategy with bioceramic and biomolecule can be a useful tool for the bone tissue engineering.
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