期刊
MACROMOLECULAR BIOSCIENCE
卷 14, 期 10, 页码 1469-1482出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400152
关键词
biodistribution; blood circulation; blood compatibility; cell viability; linear-branched hybrid polyglycerol
资金
- Canadian Institutes of Health Research (CIHR)
- Canada Foundation for Innovation
- British Columbia Knowledge Development Fund
- Michael Smith Foundation for Health Research (MSFHR)
- MSFHR
Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and branched polyglycerol are reported. Hybrid polyglycerols ((M) over barn approximate to 100 kDa) are synthesized with different compositions (15-80 mol% linear polyglycerol). Relatively small hydrodynamic size and radius of gyration of the hybrid polyglycerols suggest that they are highly compact functional nanostructures. The hybrid polyglycerols show excellent blood compatibility as determined by measuring their effects on blood coagulation, red blood cell aggregation, hemolysis, platelet, and complement activation. The cell viability in presence of hybrid polyglycerols is excellent up to 10mgmL(-1) concentration and is similar to both dextran and polyvinyl alcohol. Furthermore, tritium labeled hybrid polyglycerol shows long blood circulation (t(1/2 beta) = 34 h) with minimal organ accumulation in mice. Multifunctionality, compact nature, biocompatibility, and the long blood circulation make these polymers attractive for the development of bioconjugates and drug delivery systems.
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