期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 12, 页码 1720-1729出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300309
关键词
biomaterials; poly(ethylene glycol); protein adsorption; surface functionalization; thrombocyte adhesion
资金
- Bundesministerium fur Bildung und Forschung (BMBF) [0315696A]
The chain length and end groups of linear PEG grafted on smooth surfaces is known to influence protein adsorption and thrombocyte adhesion. Here, it is explored whether established structure function relationships can be transferred to application relevant, rough surfaces. Functionalization of poly(ether imide) (PEI) membranes by grafting with monoamino PEG of different chain lengths (M-n=1kDa or 10kDa) and end groups (methoxy or hydroxyl) is proven by spectroscopy, changes of surface hydrophilicity, and surface shielding effects. The surface functionalization does lead to reduction of adsorption of BSA, but not of fibrinogen. The thrombocyte adhesion is increased compared to untreated PEI surfaces. Conclusively, rough instead of smooth polymer or gold surfaces should be investigated as relevant models.
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