期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 5, 页码 633-640出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200420
关键词
biopolymers; drug delivery systems; hydrogels; redox polymers; stimuli-sensitive polymers
资金
- OTKA Foundation [PD76401, K 75182]
- NKTH A*STAR Hungarian Singaporean Bilateral S&T International Co-operation (BIOSPONA)
- Hungarian Academy of Sciences
Synthesis and characterization of a pH- and redox-sensitive hydrogel of poly(aspartic acid) are reported. Reversible gelation and dissolution are achieved both in dimethylformamide and in aqueous medium via a thiol-disulphide interconversion in the side chain of the polymers. Structural changes are confirmed by Raman microscopy and rheological measurements. Injectable aqueous solutions of thiolated poly(aspartic acid) can be converted into mechanically stable gels by oxidation, which can be useful for drug encapsulation and targeted delivery. Reduction-facilitated release of an entrapped drug from disulphide cross-linked hydrogels is studied.
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