期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 10, 页码 1389-1395出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300203
关键词
3D-scaffold; cell infiltration; hydroxyapatite; polycaprolactone (PCL); tissue engineering
资金
- Ministry of Knowledge and Economy, World Premier Material Program
- National Research Foundation of S. Korea
- Molecular-Level Interface Research Center [2009-0093117]
- Integrative Technology Development by Medicine and Science Fusion [2012-0006085]
In tissue engineering, fabrication of 3D scaffolds with well-defined, inter-connected pores followed by culture of mammalian cells is a typical approach. In practice, however, hydrophobicity of scaffold surfaces is not suitable for cells to be adhered because of poor wettability. Especially, infiltration followed by adhesion of cells inside hydrophobic scaffolds remains as a challenge. Thus, hydrophilic conversions of the surfaces regardless of surface location are critical for success. Herein, a method to enhance infiltration and adhesion of preosteoblasts inside hydrophobic poly(E-caprolactone) (PCL) scaffolds by a bio-inspired, hydroxyapatite formation is demonstrated. The approach can be a general method for controlling hydrophilicity of inner surfaces of scaffolds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据