期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 7, 页码 873-884出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200445
关键词
cell adhesion; hemocompatibility; hydrogels; platelet adhesion; poly(N-alkyl acrylamide); protein adsorption; surface-attached network; swelling thrombus
资金
- Deutsche Forschungsgemeinschaft, DFG [RU489/20-1]
Blood protein adsorption and blood platelet adhesion onto surface-attached poly(alkylacrylamide) networks that exhibit small and systematic variations in chemical composition are investigated. The polymer coatings are generated by depositing a thin layer of benzophenone-group-containing copolymer onto a solid substrate, followed by photo crosslinking and simultaneous surface-attachment. The correlation of the swelling of the obtained surface-attached networks with the adsorption of blood proteins and cellular adhesion is studied. The swollen surface-attached layers are inert to blood proteins and platelet cells. These results suggest that the hydrogel-coated materials are promising candidates for the generation of hemocompatible surfaces.
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