期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 6, 页码 676-681出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200463
关键词
dysfunctional platelet detection; films; patterning; platelet adhesion; surfaces
资金
- National Natural Science Foundation of China [51273199, 21274150, 51103155, 50920105302]
- National Science Foundation [CMMI 0746703, IIP 1246773]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0746703] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1246773] Funding Source: National Science Foundation
Platelets play a fundamental role in thrombus formation and in the pathogenesis of arterial thrombosis. Patterning surfaces for controlled platelet adhesion paves the way for adhesion and activation mechanisms in platelets and detection of platelet functional defects. Here, a new and simple method based on controlled polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) on the surface of styrene-block-(ethylene-co-butylene)-block-styrene (SEBS) is shown. The competition between polymerization and degradation enables platelet adhesion on SEBS to be switched on and off. The adhesive sites of the platelets can be down to single cell level, and the dysfunctional platelets can be quantitatively detected.
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