期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 6, 页码 735-744出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200475
关键词
biocompatibility; drug delivery system; folic acid (FA); poly(ethylene glycol) (PEG); single walled carbon nanotubes (SWNTs)
资金
- National Science Fund for Distinguished Young Scholars [50925310]
- National Science Foundation of China [20874059, 20904030, 21174087]
- Major Project of Chinese National Programs for Fundamental Research and Development (973 Project) [2009CB930400]
- High Technology Research and Development Program of China (863 Project) [2009AA03Z329]
- Key Fundamental Research Project of Science and Technology Commission of Shanghai Municipal Government [08JC1412300]
- Shanghai Leading Academic Discipline Project [B202]
A highly effective drug carrier is constructed by coating folic acid-terminated poly(ethylene glycol) (PEG-FA) on single walled carbon nanotubes (SWNTs) in a facile non-covalent method. The anti-cancer drug, doxorubicin (DOX), is further loaded on the surface of SWNTs at a very high loading efficiency, 149.3 +/- 4.1%. The drug system (DOX/PEG-FA/SWNTs) exhibits excellent stability under neutral pH conditions such as serum, but dramatically releases DOX at reduced pH typical of the tumour environment and intracellular lysosomes and endosomes. With the help of FA, DOX/PEG-FA/SWNTs tend to selectively attach onto cancer cells and enter the lysosomes or endosomes by clathrin-mediated endocytosis. This can greatly improve the pharmaceutical efficiency and reduce potential side effects.
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