4.7 Article

Stable Acid-Responsive Electrospun Biodegradable Fibers as Drug Carriers and Cell Scaffolds

期刊

MACROMOLECULAR BIOSCIENCE
卷 13, 期 7, 页码 885-892

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200452

关键词

acid-responsive; drug delivery systems; electrospun; fibrous scaffolds; tissue engineering

资金

  1. National Natural Science Foundation of China [51003058, 81271999, 81171437]

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Acid-responsive electrospun fibers are fabricated by introducing sodium bicarbonate into PLLA fibers using an emulsion method. This novel electrospun fibrous scaffold exhibits a rapid acid-responsive controlled drug release (early stage) and stable three-dimensional (3D) structure as a tissue engineering scaffold (late stage) for cell growth.

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