期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 2, 页码 147-154出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200269
关键词
biocompatibility; poly(N-vinylpyrrolidone); protein adsorption; surface modification
资金
- National Natural Science Foundation of China [20974086, 20974122, 20920102035]
- National Science Fund for Distinguished Young Scholars [21125418]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Poly(N-vinylpyrrolidone) (PVP), an important water soluble synthetic polymer, has many desirable properties including low toxicity, chemical stability, and good biocompatibility. Since PVP is hemocompatible and physiologically inactive, it has been used as a blood plasma substitute. Surface modification with PVP has been investigated extensively over the past few years as a means of preventing nonspecific protein adsorption. PVP may therefore be seen as a promising antifouling surface modifier comparable to poly(ethylene glycol) (PEG). In this review, various approaches for the design and preparation of PVP-modified surfaces are summarized and potential biomedical applications of these PVP-modified materials are indicated. Finally, some perspectives on future research on PVP for surface modification are discussed.
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