期刊
MACROMOLECULAR BIOSCIENCE
卷 12, 期 8, 页码 1022-1032出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100289
关键词
bone; calcium phosphate; polymers; stem cells
资金
- Jacobs Fellowship at the University of California, San Diego
- National Science Foundation [742551]
- UST-UCSD International Center of Excellence in Advanced Bio-engineering
- Taiwan National Science Council I-RiCE Program [NSC-99-2911-I-009-101]
- California Institute for Regenerative Medicine [RN2-00945]
The effect of substrate-mediated signals on osteogenic differentiation of hMSCs is studied using a synthetic bone-like material comprising both organic and inorganic components that supports adhesion, spreading, and proliferation of hMSCs. hMSCs undergo osteogenic differentiation even in the absence of osteogenesis-inducing supplements. They exhibit higher expressions of Runx2, BSP, and OCN compared to their matrix-rigidity-matched, non-mineralized hydrogel counterparts. The mineralized-hydrogel-assisted osteogenic differentiation of hMSCs could be attributed to their exposure to high local concentrations of calcium and phosphate ions in conjunction with chemical and topological cues arising from the hydrogel-bound calcium phosphate mineral layer.
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