期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 3, 页码 289-298出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200317
关键词
biocompatibility; cellulose; collagen; mechanical properties; nanocomposites
资金
- European Commission [NMP4-CT-2006-033277 TEM-PLANT]
Bio-based fibrous nanocomposites of cellulose nanofibres and non-crosslinked/crosslinked collagen were prepared by in situ pH-induced fibrillation of collagen phase and sterilized using gamma rays at 25 KGy. Collagen phase is crosslinked using genipin, a bio-based crosslinker that introduces flexible crosslinks. Microscopy studies of the prepared materials showed nanostructured fibrous collagen and cellulose dispersed in collagen matrix. Mechanical performance of the sterilized nanocomposites was close to that of natural ligament and tendon, in simulated body conditions. Cytocompatibility studies indicated that these nanocomposites allowed human ligament cell and human endothelial cell adhesion, growth, and differentiation; which is eminently favourable to ligament tissue engineering.
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