期刊
MACROMOLECULAR BIOSCIENCE
卷 12, 期 3, 页码 322-332出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100292
关键词
biomaterials; hydrogels; photopolymerization; poly(vinyl alcohol); silk sericin
资金
- Australian Government [BF010049]
- DBT [BT/PR9552/ICD/16/755/2006]
- Government of India, New Delhi
Sericin peptides and PVA are chemically modified with methacrylate groups to produce a covalent PVA/sericin hydrogel. Preservation of the sericin bioactivity following methacrylation is confirmed, and PVA/sericin hydrogels are fabricated for both B. mori and A. mylitta sericin. Cell adhesion studies confirm the preservation of sericin bioactivity post incorporation in PVA gels. PVA/A. mylitta gels are observed to facilitate cell adhesion to a significantly greater degree than PVA/B. mori gels. Overall, the incorporation of sericin does not alter the physical properties of the PVA hydrogels but does result in significantly improved cellular interaction, particularly from A. mylitta gels.
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