期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 1, 页码 59-66出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200362
关键词
adhesives; elastomeric; hydrogels; polyethylene glycol; silicate nanoparticles
资金
- Weldon School of Biomedical Engineering at Purdue University
- Office of Naval Research
- National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0952928] Funding Source: National Science Foundation
A systematic approach to develop robust and adhesive hydrogels by photopolymerizing poly(ethylene glycol) (PEG)-diacrylate and methoxy-PEG-acrylate in the presence of charged silicate nanoparticles (Laponite) is presented. PEG-diacrylate and silicate are used for covalent and physical cross-linking, thus providing the hydrogel with mechanical and adhesive strengths. Methoxy-PEG-acrylate is used as a softening agent. The resulting hydrogels can be extensively elongated and the hydrogels readily adhere to tissue even in the elongated state. These hydrogels may aid the development of adhesive tissue engineering matrixes, wound dressings, sealants, and the adhesive components of biomedical devices.
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