期刊
MACROMOLECULAR BIOSCIENCE
卷 12, 期 11, 页码 1480-1489出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200225
关键词
differentiation; hot embossing; mesenchymal stem cells; nickel nano-stamp; nano-featured polystyrene substrate
资金
- National Research Foundation of Korea (NRF) [2011-0029454, 2009-0086518]
- Korean government (MEST)
- NRF
- MEST [2011-0000412]
- National Research Foundation of Korea [2009-0086518, 2011-0029454] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, we report an efficient and cost-effective method of fabricating polystyrene (PS) nano-featured substrates containing nanopore (NPo) and nanopillar (NPi) arrays based on hot embossing using nickel nano-stamps. We investigate the behavior of adipose-derived stem cells (ASCs), including adhesion, morphology, proliferation and differentiation, on the replicated PS surfaces. Compared to a flat substrate, NPo- and NPi-featured substrates do not alter the morphology of stem cells. However, both NPo- and NPi-featured substrates induce different integrin expression and lower formation of focal adhesion complexes. In addition, ASCs on the NPo-featured substrate exhibit greater adipogenic differentiation, while the NPi-featured substrate induces higher osteogenic differentiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据