期刊
MACROMOLECULAR BIOSCIENCE
卷 12, 期 9, 页码 1190-1199出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200024
关键词
cellular uptake; glycopolymers; graft copolymers; hepatocellular carcinoma cells; nanoparticles
资金
- Thuringian Ministry for Education, Science, and Culture [B514-09051]
- Dutch Polymer Institute (DPI, Technologic Area HTE)
Chain length, size, composition, surface charge, and other properties of polymeric materials affect their recognition and uptake by cells and must be optimized to deliver polymers selectively to their target. However, it is often not possible to precisely modify selected properties without changing other parameters. To overcome these difficulties, well-defined poly(pentafluorostyrene)-based polymers are prepared that can be grafted via thiol/para-fluorine click reaction with 1-thio-beta-D-glucose and 1-thio-beta-D-galactose. Fluorescence microscopy and flow cytometry show that nanoparticles are taken up by HepG2 cells to a higher degree than the respective water-soluble polymers, and that internalization of both galactosylated homo- and nanoprecipitated block copolymers is enhanced.
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