期刊
MACROMOLECULAR BIOSCIENCE
卷 13, 期 1, 页码 93-105出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200243
关键词
cellular uptake; multishell nanoparticles; polyelectrolyte complexes; superparamagnetic iron oxide nanoparticles (SPIONs)
资金
- BMBF [03X0104D]
- Thuringian Ministry for Education, Science, and Culture (TMBWK) [B514-09051]
- NanoConSens
- ChaPoNano [B515-10065]
The coating of super-paramagnetic iron oxide nanoparticles (SPIONs) with multiple shells is demonstrated by building a layer assembled from carboxymethyldextran and poly(diallydimethylammonium chloride). Three shells are produced stepwise around aggregates of SPIONs by the formation of a polyelectrolyte complex. A growing particle size from 96 to 327?nm and a zeta potential in the range of +39 to -51?mV are measured. Microscopic techniques such as TEM, SEM, and AFM exemplify the core-shell structures. Magnetic force microscopy and vibrating sample magnetometer measurements confirm the architecture of the multishell particles. Cell culture experiments show that even nanoparticles with three shells are still taken up by cells.
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