期刊
MACROMOLECULAR BIOSCIENCE
卷 12, 期 10, 页码 1342-1353出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200042
关键词
contact guidance; fibroblasts; hydrogels; stiffness; topographical cues
资金
- NSERC Discovery Grant [RGPIN 326982-10]
- NSERC Strategic Grant [STPGP 381002-09]
- NSERC-CIHR Collaborative Health Research Grant [CHRPJ 385981-10]
- HSFO [T6946]
- Discovery Accelerator Supplement [RGPAS 396125-10]
Previous studies demonstrated the importance of substrate stiffness and topography on the phenotype of many different cell types including fibroblasts. Yet the interaction of these two physical parameters remains insufficiently characterized, in particular for cardiac fibroblasts. Most studies focusing on contact guidance use rigid patterned substrates. It is not known how the ability of cardiac fibroblasts to follow grooves and ridges changes as the substrate stiffness is decreased to match the range of stiffness found in native heart tissues. This report demonstrates a significant interactive effect of substrate stiffness and topography on cardiac fibroblast elongation and orientation using polyacrylamide substrates of different stiffness and topography.
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