期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 4, 页码 467-482出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000397
关键词
biomaterials; elastomers; polymer; tissue engineering
资金
- Carnegie Mellon University
- Berkman Faculty Development Fund
Synthetic biomaterials serve as a cornerstone in the development of clinically focused regenerative medicine therapies that aim to reduce suffering and prolong life. Recent improvements in biodegradable elastomeric materials utilize natural extracellular matrix proteins as inspiration to yield a new class of materials with superior degradation kinetics, desirable biocompatibility profiles, and mechanical properties that closely match those of soft tissues. This review describes several classes of synthetic biodegradable elastomers and associated fabrication techniques that are relevant to scaffold development. The application of these materials to select tissue engineering models is also discussed.
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