期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 4, 页码 549-556出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000419
关键词
anticoagulant coatings; blood compatibility; cellulose sulfates; chitosan; layer-by-layer assemblies
资金
- Bundesministerium fur Landwirtschaft und Verbraucherschutz
- Fachagentur Nachwachsende Rohstoffe e.V. [22021905]
- European Polysaccharide Network of Excellence (EPNOE)
In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material.
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