期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 5, 页码 700-709出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000509
关键词
biological application of polymers; elastomers; neointimal hyperplasia; nitric oxide; vascular
资金
- NSF-NSEC
- NSF-MRSEC
- Keck Foundation
- State of Illinois
- Northwestern University
- National Institutes of Health (NIH) [1 K08HL084203, N01-CO-2008-00001, HHSN261200800001E]
- American Vascular Association
- Alpha Omega Alpha Honor Medical Society
- National Cancer Institute (NCI)
- NIH, NCI, Center for Cancer Research
- Ministerio de Ciencia e Innovacion of Spain
The synthesis of poly(diol-co-citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO-mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury model, these materials demonstrate a significant reduction of neointimal hyperplasia. This is the first report of a NO-releasing polymer fabricated in the form of an elastomeric perivascular wrap for the treatment of neointimal hyperplasia. These elastomers also show promise for other cardiovascular pathologies where NO-based therapies could be beneficial.
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