期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 11, 页码 1526-1536出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100141
关键词
biocompatibility; collagen-like; core/shell polymers; emulsion electrospinning; release
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
The effectiveness of a multifunctional scaffold produced by the electrospinning of emulsions composed of organic PLGA and aqueous collagen-like protein (denoted as Fol-8Col) solutions is demonstrated. The resultant Fol-8Col/PLGA fibrous scaffolds with homogeneous morphology have mean fiber diameters from 600 to 2 000 nm. A uniform distribution of encapsulated Fol-8Col in the fibers is observed by fluorescence microscopy. TEM is used to clarify the representative core/sheath structure of emulsion electrospun Fol-8Col/PLGA fibers. Preliminary release assessment of encapsulated Fol-8Col shows results of sustained release for more than one month from the Fol-8Col/PLGA fibrous mats. The cytocompatibility of fibroblast cell line L929 with the fibrous composite seems promosing.
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