期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 4, 页码 493-502出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000390
关键词
fibers; luminal side coating; monolayer; non-thrombogenic; PEG; PET; platelets; small diameter vascular grafts
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Biomedical Science and Technology Research Group (GRSTB)
- Fonds de la recherche en sante du Quebec (FRSQ)
Vascular PET grafts (Dacron) have shown good performance in large vessels (>= 6 mm) applications. To address the urgent unmet need for small-diameter (2-6 mm) vascular grafts, proprietary high-compliance nonwoven PET fiber structures were modified with various PEG concentrations using PVA as a cross-linking agent, to fabricate non-thrombogenic mechanically compliant vascular grafts. The blood compatibility assays measured through platelet adhesion (SEM and mepacrine dye) and platelet activation (morphological changes, P-selectin secretion, and TXB2 production) demonstrate that functionalization using a 10% PEG solution was sufficient to significantly reduce platelet adhesion/activation close to optimal literature-reported levels observed on carbon-coated ePTFE.
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