期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 5, 页码 673-679出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000479
关键词
adhesion; biological applications of polymers; biomaterials; hydrogels; tissue engineering
资金
- Korean Government [NRF-2009-351-1-D00045]
- Ministry of Knowledge Economy (MKE, Korea) [10030914]
- Korea Institute of Industrial Technology(KITECH) [10030914] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin alpha 1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.
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