期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 6, 页码 828-838出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000473
关键词
anionic polymers; biomaterials; drug delivery systems; hyperbranched polysulfonamines
资金
- China National Funds for Distinguished Young Scientists [21025417]
- National Natural Science Foundation of China [20974062]
- National Basic Research Program [2009CB930400]
- Fok Ying Tung Education Foundation [111048]
- Shuguang Program [08SG14]
- Shanghai Leading Academic Discipline Project [B202, S30203]
Efficient intracellular translocation is achieved using an easily prepared hyperbranched polysulfonamine that remains negatively charged at physiological pH. Investigations on the cellular uptake mechanism and the subcellular distribution of PSA are reported. The in vitro cytotoxicity of PSA is found to be low. Using doxorubicin as a model drug, a PSA/drug complex is prepared by electrostatic interaction with a high drug payload that exhibits a controlled release in response to pH. Efficient intracellular drug delivery, strong growth inhibition of tumor cells, and low cytotoxicity to normal cells are observed. The results suggest a possible way to utilize anionic polymers for intracellular delivery of therapeutic moieties or drugs.
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