期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 6, 页码 806-813出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000465
关键词
blending; conducting polymers; diblock copolymers; self-organization; tissue engineering
资金
- National Natural Science Foundation of China [50773081, 50973109, 50733003]
- Ministry of Science and Technology of China [2007AA03Z320]
- Program of Scientific Development of Jilin Province [20095003]
A novel PGTA diblock copolymer containing electroactive TEA and mPEG is described. Biodegradable PLLA/PGTA polymer blends are shown to be electroactive. Nanopores of different sizes can be formed on the surface of the polymer blends. An MTT assay shows that the PLLA/PGTA blends exhibited reduced cytotoxicity as compared to TEA due to the introduction of the biocompatible PLLA moiety. Cell culture results show that the cells grow better when they were adhered to the surface of the PLLA/PGTA blends. The 80/20 wt.-% PLLA/PGTA blend shows the best biocompatibility and an electroactivity that accelerates the differentiation of rat C6 glioma cells.
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