期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 10, 页码 1325-1330出版社
WILEY-BLACKWELL
DOI: 10.1002/mabi.201100119
关键词
artificial extracellular matrices; degradation; epithelial morphogenesis; hydrogels; tissue engineering
资金
- NIH [GM008347]
In situ forming physical hydrogels are formed through a biologically benign reaction between two multi-arm macromers, one containing terminal thiol and the other containing terminal vinyl sulfone groups. One macromer is self-assembled through a coiled-coil domain; and the physical junction of this macromer confers the physical nature to the whole network. Unlike covalently cross-linked hydrogels in which material degradation is a prerequisite for three-dimensional cell movement, these physical hydrogels have junctions that undergo reversible dissociation and re-association, constitutively opening paths for cell movement. Epithelial cells encapsulated in these hydrogels can form hollow spherical cysts without the need for material degradation.
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