期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 12, 页码 1684-1692出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100229
关键词
cartilage; degradation; electrospinning; functionalization of polymers; poly(e-caprolactone)
资金
- Dutch Program for Tissue Engineering (DPTE) [6731]
Scaffolds based on a novel functionalized polyester, pHMGCL, are electrospun and characterized morphologically and physically. In vitro degradation studies of pHMGCL films show considerable mass loss and molecular weight reduction within 70 weeks. Scaffolds composed of fibers with uniform diameter (approximate to 900nm) and with melting temperatures higher than body temperature are prepared. As an indication for the feasibility of this material for regenerative medicine approaches, articular chondrocytes are seeded onto electrospun pHMGCL scaffolds. Chondrocytes attach to the fibers and re-differentiate as demonstrated by the production of GAG and collagen type II within four weeks of in vitro culture. Hydrophilic pHMGCL scaffolds may thus be useful for tissue engineering applications.
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