期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 9, 页码 1218-1226出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100071
关键词
atmospheric plasma; heparin; LDL absorbents; polysulfone membranes; surface modifications
资金
- National Natural Science Foundation of China [50703034]
- Fresenius Medical Care Deutschland GmbH's Nephrocore Program for Young Scientists
- Zhejiang Provincial Natural Science Foundation of China [Y4110606]
- Fundamental Research Funds for the Central Universities (MOE Engineering Research Center of Membrane and Water Treatment Technology) [KYJD09011]
A simple, convenient and economical method for the heparinization of PSf membranes is described, with the aim of preparing an LDL adsorber for simultaneous LDL apheresis and hemodialysis. An atmospheric pressure glow discharge generator is used to activate the PSf membrane surface, with subsequent chemical binding of heparin in the presence of EDC and NHS. ATR-FTIR spectroscopy and XPS measurements confirm successful surface modification. The PSf-Hep membrane shows good blood compatibility, with a relatively low amount and normal morphology of adherent platelets. ELISA results indicate that the PSf-Hep membrane exhibits excellent selective affinity for LDL in single and binary protein solutions, suggesting potential applications in hemodialysis with simultaneous LDL removal.
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