期刊
MACROMOLECULAR BIOSCIENCE
卷 10, 期 12, 页码 1416-1423出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000053
关键词
adhesion; biocompatibility; layered silicates; nanocomposites; nanoparticles
资金
- NSF [0711783]
- Purdue Lynn Doctoral fellowship
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0711783] Funding Source: National Science Foundation
Controlling cell adhesion on a biomaterial surface is associated with the long-term efficacy of an implanted material. Here we connect the material properties of nanocomposite films made from PEO physically cross-linked with layered silicate nanoparticles (Laponite) to cellular adhesion. Fibroblast cells do not adhere to pure PEO, but they attach to silicate containing nanocomposites. Under aqueous conditions, the films swell and the degree of swelling depends on the nanocomposite composition and film structure. Higher PEO compositions do not support cell proliferation due to little exposed silicate surfaces. Higher silicate compositions do allow significant cell proliferation and spreading. These bio-nanocomposites have potential for the development of biomedical materials that can control cellular adhesion.
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