期刊
MACROMOLECULAR BIOSCIENCE
卷 11, 期 1, 页码 36-49出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000245
关键词
biocompatibility; biological application of polymers; biomaterials; nanotechnology
资金
- AHA Scientist Development Grant
- March of Dimes-O'Conner
The biochemical cues and topographical architecture of the extracellular environment extensively influence ES cell fate. The microenvironment surrounding the developing embryo presents these instructive cues in a complex and interactive manner in order to guide cell fate decisions. Current stem cell research aims to reconstruct this multifaceted embryonic niche to recapitulate development in vitro. This review focuses on 2D and 3D differentiation niches created from natural and synthetic biomaterials to guide the differentiation of ES cells toward specific lineages. Biomaterials engineered to present specific physical constraints are also reviewed for their role in differentiation.
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