期刊
MACROMOLECULAR BIOSCIENCE
卷 10, 期 2, 页码 173-182出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900169
关键词
differential scanning calorimetry; human mesenchymal stem cells; hydroxyapatite; fibers; osteogenic differentiation
资金
- Seoul Development Institute [CR070027]
We fabricated composite fibrous scaffolds from blends of poly (lactide-co-glycolide) (PLGA) and nano-sized hydroxyapatite (HA) via electrospinning. SEM-EDX and AFM analysis demonstrated that HA was homogeneously dispersed in the nanofibers, and the roughness increased along with the amount of incorporated HA. When hMSCs were cultured on these PLGA/HA composite nanofibers, we found that incorporation of HA on the nanofibers did not affect cell viability whereas increased ALP activity and expression of osteogenic genes as well as the calcium mineralization of hMSCs. Our results indicate that the composite nanofibers can be offered as a potential bone regenerative biomaterial for stem cell based therapies.
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