期刊
MACROMOLECULAR BIOSCIENCE
卷 10, 期 3, 页码 265-270出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900363
关键词
biomaterials; electrospinning; hyaluronic acid; photopatterning; photopolymerization
资金
- David and Lucile Packard Foundation
- National Institute of Health [R01AR056624]
The structural and mechanical properties of tissue engineered environments are crucial for successful cellular growth and tissue repair. Electrospinning is gaining wide attention for the fabrication of tissue engineered scaffolds, but the small pore sizes of these scaffolds limit cell infiltration and construct vascularization. To address this problem, we have combined electrospinning with photopatterning to create multiscale porous scaffolds. This process retains the fibrous nature of the scaffolds and permits enhanced cellular infiltration and vascularization when compared to unpatterned scaffolds. This is the first time that photopatterning has been utilized with electrospun scaffolds and is only now possible with the electrospinning of reactive macromers.
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