期刊
MACROMOLECULAR BIOSCIENCE
卷 10, 期 8, 页码 916-924出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000034
关键词
drug delivery systems; micelles; radiation; synthesis; thermal properties
资金
- Academy of Sciences of the Czech Republic [KAN 200200651]
- Grant Agency of the Czech Republic [P207/10/P054, 202/09/2078]
- Ministry of Education, Youth and Sports of the Czech Republic [IM 4635608802]
Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5-10 x 10(-5) g . mL(-1) with diameter approximate to 200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions.
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