期刊
MACROMOLECULAR BIOSCIENCE
卷 10, 期 12, 页码 1527-1535出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000100
关键词
biodegradable; composite materials; controlled drug delivery; nanoparticles; nanofiber non-wovens
资金
- Department of Pharmaceutical Technology and Biopharmaceutics, University of Marburg
- German Research Foundation (DFG) [FOR 627]
Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.
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